Eleven-year-old Sam McQueen, who has leukemia, writes a book during the last three months of his life, in which he tells about what he would like to accomplish, how he feels, and things that have happened to him.
Twelve-year-old cancer survivor Norah struggles to fit in at middle school after two years of treatment, but she finds her voice with the help of new friend Griffin, who shares her love of mythology.
Seventeen-year-old Greg has managed to become part of every social group at his Pittsburgh high school without having any friends, but his life changes when his mother forces him to befriend Rachel, a girl he once knew in Hebrew school who has leukemia.